K9 Advantix

No More Fleas, Ticks and Mosquitoes!

Fight against fleas, ticks, and mosquitoes with K9 Advantix! This topical treatment is available in 4, 6, and 12 month treatments for dogs of all sizes. K9 Advantix will not lose most of it's effectiveness and will still provide exceptional protection against fleas, ticks, and mosquitoes after baths and swimming. Purchase K 9 Advantix at a discount to prevent your dog, as well as yourself, from dealing with these pesky pet parasites.

K9 Advantix is for use on dogs and puppies 7 weeks of age and older only. It is used for the relevant prevention and treatment of fleas, mosquitoes and ticks including deer ticks (the major carrier of Lyme disease), American dog ticks, Brown dog ticks and lone star ticks.

The active ingredients, imidacloprid and permethrin, work together for a quick knockdown by affecting the flea, mosquito or tick's nervous system. Because K9 Advantix® provides such quick knockdown of these insects it can helpful in limiting the spread of the West Nile Virus and Lyme Disease. It is also ideal for dogs suffering from Flea Allergy Dermatitis.

k9 Advantix for dogs is effective flea and tick treatment for dogs.When a flea is exposed to imidacloprid on a treated pet, the compound is absorbed through the insect's intersegmental membrane. Here, the compound comes into contact with the flea's nervous system. Imidacloprid then acts inside the synapse of the insect to disrupt transmission of the nervous impulse. Imidacloprid binds to post-synaptic nicotinic receptor sites inside the synapse, essentially "locking" the receptor in the open position thus hyperstimulating the cell. As this occurs throughout the nervous system, it leads to death of the insect. Furthermore, imidacloprid is highly selective in its activity. It only binds to insect nicotinic receptor sites, showing virtually no affinity for mammalian receptor sites. As an analogy, one may think of a lock and key, where the insect nicotinic receptor site is the lock and imidacloprid is the key. Imidacloprid only "fits" the right "lock," and does not fit similar receptor sites found in mammals.

The highly specific mode of action of imidacloprid makes it an ideal compound for insect control. However, it does limit its utility against ticks and mites because they are arachnids (the same class as spiders) rather than insects. Research has shown that imidacloprid does not bind as well to arachnid receptors as it does to insect receptors. For this reason, imidacloprid is not utilized as a stand-alone ingredient for canine tick control. Rather, its limited activity against ticks is best exploited to enhance the efficacy of other compounds, permethrin in particular.


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